New research published in Cell Metabolism could prove to be beneficial to patients with diabetes. The study is a joint collaboration between JDRF- funded researchers and the pharmaceutical company Hoffmann-La Roche.
The study has identified a protein that regulates beta cell growth and a chemical that stimulates cell growth; this could lead to a new drugs target for the treatment of type one diabetics
The study was headed by Markus Stoffel, M.D., Ph.D., a professor at the Swiss Federal Institute of Technology in Zurich, and could lead to new drugs which could stimulate beta cell regeneration.
The research is a continuation of a study carried out five years ago which identified a protein called Tmem27. During a mouse trial the researchers discovered that increased amounts of the protein in beta cells were associated with an increased number of islets. It was also found that if the protein was cut, the protein was no longer effective.
Further research showed that if another protein named Bace-2 was inhibited then this could encourage the growth of beta cells.
Commenting in a press release, Patricia Kilian, Ph.D., scientific program director of regeneration research at JDRF, said:
"This is an exciting and potentially impactful finding.”
"It's an example of how researchers make an early observation and follow up on it, and then take it to the next level where it has translational potential - the potential to be developed into a drug that promotes the growth of beta cells for diabetes."
Source: http://www.jdrf.org/index.cfm?page_id=116203
The study has identified a protein that regulates beta cell growth and a chemical that stimulates cell growth; this could lead to a new drugs target for the treatment of type one diabetics
The study was headed by Markus Stoffel, M.D., Ph.D., a professor at the Swiss Federal Institute of Technology in Zurich, and could lead to new drugs which could stimulate beta cell regeneration.
The research is a continuation of a study carried out five years ago which identified a protein called Tmem27. During a mouse trial the researchers discovered that increased amounts of the protein in beta cells were associated with an increased number of islets. It was also found that if the protein was cut, the protein was no longer effective.
Further research showed that if another protein named Bace-2 was inhibited then this could encourage the growth of beta cells.
Commenting in a press release, Patricia Kilian, Ph.D., scientific program director of regeneration research at JDRF, said:
"This is an exciting and potentially impactful finding.”
"It's an example of how researchers make an early observation and follow up on it, and then take it to the next level where it has translational potential - the potential to be developed into a drug that promotes the growth of beta cells for diabetes."
Source: http://www.jdrf.org/index.cfm?page_id=116203
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